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Publications

2017

Revue

Hyenne V, Lefebvre O and Goetz JG

Going live with tumor exosomes and microvesicles. Cell Adh Migr. In press.

2016

Lee K-Z, Lestradet M, Socha C, Schirmeier S, Schmitz A, Spenlé C, Lefebvre O, Keime C, Yamba WM, Bou Aoun R, Liegeois S, Schwab Y, Simon-Assmann P, Dalle F, Ferrandon D. 2016.  Enterocyte Purge and Rapid Recovery Is a Resilience Reaction of the Gut Epithelium to Pore-Forming Toxin Attack. Cell Host & Microbe 20:716‑730.

Rupp T, Langlois B, Radwanska A, Koczorowska MM, Zhen S, Hussenet T, Lefebvre O, Murdamoothoo D, Arnold A, Klein A, Biniossek ML, Hyenne V, Naudin E, Velazquez-Quesada I, Schilling O, Van Obberghen-Schilling E, Orend G*. Tenascin-C orchestrates glioblastoma angiogenesis by modulation of pro and anti angiogenic signaling. Cell Reports, 17, 2607–2619.

Jacob L, Sawma P, Garnier N, Meyer L, Fritz J, Hussenet T, Spenlé C, Jacky Goetz J, Fernandez A, Baumlin N, Aci-Sèche S, Orend G, Roussel G, Crémel G, Genest M, Hubert P, Bagnard D. 2016. Inhibition of PlexA1-mediated brain tumor growth and tumor-associated angiogenesis using a transmembrane domain targeting peptide. Oncotarget. 7, 57851–57865.

Mammadova-Bach E, Zigrino P, Brucker C, Bourdon C, Freund M, De Arcangelis A, Abrams S, Orend G, Gachet C, Mangin PH. 2016. Platelet integrin α6β1 controls lung metastasis through direct binding to cancer cell-derived ADAM9. JCI Insight. 2016 Sep 8;1(14):e88245.

Arpel A, Gamper C, Spenlé C, Fernandez A, Jacob L, Baumlin N, Laquerriere P, Orend G, Crémel G, Bagnard B. 2016. Inhibition of primary breast tumor growth and metastasis using a neuropilin-1 transmembrane domain interfering peptide. Oncotarget, 7, 54723–54732.

De Arcangelis A, Hamade H* Alpy F, Normand S, Bruyère E,  Lefebvre O,  Méchine-Neuville A, Siebert S, Pfister V, Lepage P,  Laquerriere P, Dembele D, Delanoye-Crespin A, Rodius S, Robine S, Kedinger M, Van Seuningen I, Simon-Assmann P, Chamaillard M, Labouesse M, Georges-Labouesse E. 2016. Hemidesmosome integrity protects the colon against colitis and colorectal cancer. Gut, gutjnl-2015-310847.                                                                                                         

Mercier L, Böhm J, Fekonja N, Allio G, Lutz Y, Koch M, Goetz JG*, Laporte J*. In vivo imaging of skeletal muscle in mice highlights muscle defects in a mouse model of myotubular myopathy. 2016. Intravital. 5, e1168553. *co-corresponding authors.

Tierney MT, Gromova A, Sesillo FB, Sala D, Spenlé C, Orend G, Sacco A. 2016. Autonomous extracellular matrix remodeling controls a progressive adaptation in muscle stem cell regenerative capacity during development. Cell Reports, 14, 1940-1952

Quintin S, Wang S, Pontabry J, Bender A, Robin F, Hyenne V, Landmann F, Gally C, Oegema K, Labouesse M. 2016. Non-centrosomal epidermal microtubules act in parallel to LET-502/ROCK to promote C. elegans elongation. Development, 143, 160-173

Karreman MA, Mercier L, Schieber NL, Solecki G, Allio G, Winkler F, Ruthensteiner B,  Goetz* JG, Schwab* Y. 2016. Fast and precise targeting of single tumor cells in vivo by multimodal correlative microscopy. J Cell Sci.129, 444 – 456. * co-corresponding authors.

2015

Maurer E, Schaff M, Receveur N, Bourdon C, Mercier L,  Nieswandt B, Dubois C, Jandrot-Perrus M, Goetz JG, Lanza F, Gachet C, Mangin PH. Fibrillar cellular fibronectin supports efficient platelet aggregation and procoagulant activity. 2015. Thromb Haemost. 114, 1175-1188

Hyenne V, Apaydin A, Rodriguez D, Spiegelhalter C, Hoff-Yoessle S, Diem M, Tak S, Lefebvre O, Schwab Y, Goetz JG and Labouesse M. 2015. RAL-1 controls multivesicular body biogenesis and exosome secretion. J Cell Biol, 211, 27-37

Buchert M, Rohde F, Eissmann M, Tebbutt N, Williams B, Tan CW, Owen A, Hirokawa Y, Gnann A, Orend G, Orner G, Dashwood RH, Heath JK, Ernst M, Janssen KP. 2015. A hypermorphic epithelial beta-catenin mutation facilitates intestinal tumorigenesis in mice in response to compounding WNT-pathway mutations. 2015. Dis Model Mech, 8, 1361-1373

Zeniou M, Fève M, Mameri S, Dong J, Salomé C, Chen W, El-Habr EA, Bousson F, Sy M, Obszynski J, Boh A, Villa P, Assad Kahn S, Didier B, Bagnard D, Junier MP, Chneiweiss H, Haiech J, Hibert M, Kilhoffer MC. 2015. Chemical library screening and structure-function relationship studies identify bisacodyl as a potent and selective cytotoxic agent towards quiescent human glioblastoma tumor stem-like cells. PLoS One 10, e0134793

Leriche G, Nothisen M, Baumlin N, Muller CD, Bagnard D, Remy JS, Jacques SA, Wagner A. 2015. Spiro Diorthoester (SpiDo), a human plasma stable acid-sensitive cleavable linker for lysosomal release. Bioconjug Chem 26, 1461-1465

Spenlé C*, Gasser I*, Saupe F*, Janssen KP, Arnold C, Klein A, van der Heyden M, Mutterer J, Neuville-Méchine A, Chenard MP, Guenot D, Esposito I, Slotta-Huspenina J, Amburtsumian N, Simon-Assmann P, Orend G. 2015. Spatial organization of the tenascin-C microenvironment in experimental and human cancer. Cell Adh Migr, 9, 4-13 * first co-authors

2014

Xu DE, Zhang WM, Yang ZZ, Zhu HM, Yan K, Li S, Bagnard D, Dawe GS, Ma QH, Xiao ZC. 2014, Amyloid precursor protein at node of Ranvier modulates nodal formation. Cell Adh Migr. 8,396-403

Karreman MA, Mercier L, Schieber N, Shibue T, Schwab Y, Goetz JG. 2014. Correlating intravital multi-photon microscopy to 3D electron microscopy of invading tumor cells using anatomical reference points. PLoS One, 9, e114448

Langlois B, Saupe F, Rupp T, Arnold C, van der Heyden M, Orend G*, Hussenet T*. 2014. AngioMatrix, a signature of the tumor angiogenic switch-specific matrisome, correlates with poor prognosis for glioma and colorectal cancer patients. Oncotarget, 5, 10529-10545 * corresponding authors

Spenlé C, Lefebvre O, Lacroute J, Méchine-Neuville A, Barreau F, Blottière HM, Duclos B, Arnold C, Hussenet T, Hemmerlé J, Gullberg D, Kedinger M, Sorokin L, Orend G, Simon-Assmann P. 2014. The laminin response in inflammatory bowel disease: protection or malignancy? PLoS One, 9, e111336.

Abada S, Lecointre A, Christine C, Ehret-Sabatier L, Saupe F, Orend G, Brasse D, Ouadi A, Hussenet T, Laquerrière P, Elhabiri M, Charbonnière LJ.2014. Phosphonated chelates for nuclear imaging. Org Biomol Chem, 12, 9601-9620

Sawma P, Roth L, Blanchard C, Bagnard D, Crémel G, Bouveret E, Duneau JP, Sturgis JN, Hubert P. 2014. Evidence for new homotypic and heterotypic interactions between transmembrane helices of proteins involved in receptor tyrosine kinase and neuropilin signalingJ Mol Biol, 426, 4099-4111

Fernandez A, Le Bon C, Baumlin N, Giusti F, Crémel G, Popot JL, Bagnard D. 2014. In vivo characterization of the biodistribution profile of Amphipol A8-35. J Membr Biol, 247, 1043- 1051

Arpel A, Sawma P, Spenlé C, Fritz J, Meyer L, Garnier N, Velásquez-Quesada I, Hussenet T, Aci-Sèche S ,Baumlin N, Duneau JP, Genest M, Brasse D, Hubert P, Crémel G, Orend G, Laquerrière P, Bagnard D. 2014.Transmembrane domain targeting peptide antagonizing ErbB2/Neu inhibits breast tumor growth and metastasis. Cell Reports, 8, 1714-1721

Treinys R, Kaselis A, Jover E, Bagnard D, Satkauskas S. 2014. R-type calcium channels are crucial for semaphorin 3A-induced DRG axon growth cone collapse. PLoS One, 17, 9, e102357.

Ehninger A, Boch T, Medyouf H, Mudder K, Orend G, Trumpp A. 2014. Loss of SPARC protects hematopoietic stem cells from chemotherapy toxicity by accelerating their return to quiescence. Blood, 123, 4054-4063

Aci-Sèche S, Sawma P, Hubert P, Sturgis JN, Bagnard D, Jacob L, Genest M, Garnier N. 2014. Transmembrane recognition of the semaphorin co-receptors neuropilin 1 and plexin A1: coarse-grained simulations. PLoS One 23, 9:e97779.

Goetz JG, Steed E, Ferreira RR, Roth S, Ramspacher C, Boselli G, Charvin G,  Liebling M,  Wyart C,  Schwab Y, and  Vermot J. Endothelial cilia mediate low flow sensing during zebrafish vascular development. Cell Reports,13;6(5):799-808.

2013

Saupe F*, Schwenzer A*, Jia Y*, Gasser I, Spenlé C, Langlois B, Kammerer M, Lefebvre O, Hlushchuk R, Rupp T, Marko M, van der Heyden M, Cremel G, Arnold C, Klein A, Simon-Assmann P, Djonov V, Neuville-Méchine A, Esposito I, Slotta-Huspenina J, Janssen K-P, de Wever O, Christofori G, Hussenet Tº, Orend Gº. 2013. Tenascin-C downregulates wnt inhibitor Dickkopf-1, promoting tumorigenesis in a neuroendocrine tumor model. Cell Reports, 5: 482-92. * co-authors ° co-corresponding authors.

Ruediger T, Zimmer G, Barchmann S, Castellani V, Bagnard D, Bolz J. 2013. Integration of opposing semaphorin guidance cues in cortical axons. Cereb Cortex. 23:604-14.

Schaff M, Tang C, Maurer E, Bourdon C, Receveur N, Eckly A, Hechler B, Arnold C, de Arcangelis A, Nieswandt B, Denis CV, Lefebvre O, Georges-Labouesse E, Gachet C, Lanza F, Mangin PH. 2013. Integrin α6β1 is the main receptor for vascular laminins and plays a role in platelet adhesion, activation and arterial thrombosis. Circulation, 128:541-52.

Spenlé C, Simon-Assmann P, Orend G, Miner JH. 2013. Laminin α5 guides tissue patterning and organogenesis, Cell Adh Migr. 7, 90-100.

Simon-Assmann P. 2013.The laminin family: founding members of the basement membrane. Cell Adh Migr. 7, 44-47, guest editor (editorial)

Edwards MM, Lefebvre O. 2013. Laminins and retinal vascular development. Cell Adh Migr. 7:82-9.

2012

Ritié L *, Spenlé C *, Lacroute J, Bolcato-Bellemin A-L, Lefebvre O, Bole-Freysot C, Jost B, Klein A, Arnold C, Kedinger M, Bagnard D, Orend G, Simon-Assmann P. 2012. Abnormal Wnt and PI3Kinase signaling in the malformed intestine of lama5 deficient mice. PLoS One, 2012, 7,e37710. * co-first authors

Brellier F, Martina E, Chiquet M, Ferralli J, van der Heyden M, Orend G, Schittny JC, Chiquet-Ehrismann R, Tucker RP. 2012. The adhesion modulating properties of tenascin-W. Int J Biol Sci. 8:187-94.

Noel G, Schott R, Froelich S, Gaub MP, Boyer P, Fischer-Lokou D, Dufour P, Kehrli P, Maitrot D. 2012. Retrospective comparison of chemoradiotherapy followed by adjuvant chemotherap with or without prior Gliadel implantation (Carmustine) after initial surgery in patients with newly diagnosed high-grade gliomas. Int J Radiat Oncol Biol Phys 82:749-55

Zylbersztejn K, Petkovic M, Burgo A, Deck M, Garel S, Marcos S, Bloch-Gallego E, Nothias F, Serini G, Bagnard D, Binz T, Galli T. 2012. The vesicular SNARE Synaptobrevin is required for Semaphorin 3A axonal repulsion. J Cell Biol. 196:37-46.

Freund JB, Goetz JG, Hill KL, Vermot J. 2012. Fluid flows and forces in development: functions, features and biophysical principles. 2012. Development. 139:1229-45. Review. Erratum in: Development. 2012, 139:3063.

Christine C, Koubemba M, Shakir S, Clavier S, Ehret-Sabatier L, Saupe F, Orend G, Charbonnière LJ. 2012. Synthesis of an activated phosphonated bifunctional chelate with potential for PET imaging and radiotherapy. Org Biomol Chem. 10:9183-90.

Beucher A, Martín M, Spenle C, Poulet M, Collin C, Gradwohl G. Competence of failed endocrine progenitors to give rise to acinar but not ductal cells is restricted to early pancreas development. 2012. Dev Biol. 361:277-85.

Perrot G, Langlois B, Devy J, Jeanne A, Verzeaux L, Almagro S, Sartelet H, Hachet C, Schneider C, Sick E, David M, Khrestchatisky M, Emonard H, Martiny L, Dedieu S. 2012. LRP-1-CD44, a new cell surface complex regulating tumor cell adhesion. Mol. Cell. Biol. 32:3283-07.

Spenlé C, Hussenet T, Lacroute J, Lefebvre O, Kedinger M, Orend G, Simon-Assmann P. 2012. Dysregulation of laminins in intestinal inflammation. Special issue “50th Anniversary - French Society for connective tissue research”, 2012, Pathologie Biologie, 60: 41-47.

Goetz JG. 2012. Tumor microenvironment indoctrination: an emerging hallmark of cancer. Cell Adh Migr. 6:190-2.

2011

Destouches D, Page N, Hamma-Kourbali Y, Machi V, Chaloin O, Frechault S, Birmpas C, Katsoris P, Beyrath J, Albanese P, Maurer M, Carpentier G, Strub JM, Van Dorsselaer A, Muller S, Bagnard D, Briand JP & Courty J. 2011. A simple approach to cancer therapy afforded by multivalent pseudopeptides that target cell-surface nucleoproteins. Cancer Res 71:3296-3305.

Popot JL, Althoff T, Bagnard D, Banères JL, Bazzacco P, Billon-Denis E, Catoire LJ, Champeil P, Charvolin D, Cocco MJ, Crémel G, Dahmane T, de la Maza LM, Ebel C, Gabel F, Giusti F, Gohon Y, Goormaghtigh E, Guittet E, Kleinschmidt JH, Kühlbrandt W, Le Bon C, Martinez KL, Picard M, Pucci B, Sachs JN, Tribet C, van Heijenoort C, Wien F, Zito F, Zoonens M.. 2011. Amphipols from A to Z. Annu Rev Biophys 40:379-408.

Page N. Gros F, Schall N, Decossas M, Bagnard D, Briand JP, & Muller S. 2011. HSC70 blockade by the therapeutic peptide P140 affects autophagic processes and endogenous MHCII presentation in murine lupus. Ann Rheum Dis 70:837-843.

Schaff M, Receveur N, Bourdon C, Wurtz V, Denis CV, Orend G, Gachet C, Lanza F, & Mangin PH. 2011. Novel function of tenascin-C, a matrix protein relevant to atherosclerosis, in platelet recruitment and activation under flow. Arterioscler Thromb Vasc Biol 31:117-124.

Edwards MM, McLeod DS, Grebe G, Heng C, Lefebvre O & Lutty GA. 2011. Lama1 mutations lead to vitreoretinal blood vessel formation, persistence of fetal vasculature and epiretinal membrane formation in mice. BMC Dev Biology. 11:60.

Heng C, Lefebvre O, Klein A, Edwards MM, Simon-Assmann P, Orend G, Bagnard D. 2011. Functional role of laminin α1 chain during cerebellum development. Cell Adh Migr. 5:480-9.

Goetz JG*, Minguet S, Navarro-Lérida I, Lazcano JJ, Samaniego R, Calvo E, Tello M, . Osteso-Ibáñez T, Pellinen T, Echarri A, Cerezo A, Klein-Szanto AJP, Garcia R,. Keely PJ, Sánchez-Mateos P, Cukierman E, del Pozo MA *. (* Co-corresponding authors). 2011. Biomechanical remodeling of the microenvironment by stromal Cav1 favors tumor invasion and metastasis. Cell, 146,148-163.  (Selected for the PaperFlick on Cell website, Highlighted in Nature, Nature’s Cell migration gateway, Faculty of 1000)

Goetz JG, Del Pozo MA. 2011. Caveolin-1 forces matrix remodeling. Med Sci (Paris). 27:940-4.

Holl N, Noblet V, Rodrigo S, Dietemann JL, Mekhbi MB, Kehrli P, Wolfram-Gabel R, Braun M, Kremer S. 2011. Temporal lobe association fiber tractography as compared to histology and dissection. Surg Radiol Anat 33, 713-722.

Simon-Assmann P, Orend G, Mammadova-Bach E, Spenlé C, & Lefebvre O. 2011. Role of laminins in physiological and pathological angiogenesis. Special issue “Angiogenesis in Development and Cancer” (Djonov V and Ribatti D; eds). Int J Develop Biol, 55:455-465.

Van Obberghen-Schilling E, Tucker RP, Saupe F, Gasser I, Cseh B, & Orend G. 2011. Fibronectin and tenascin-C: accomplices in vascular morphogenesis during development and tumor growth. Special issue “Angiogenesis in Development and Cancer” (Djonov V and Ribatti D; eds). Int J Develop Biol, 55:511-525.

Midwood K*, Hussenet T, Langlois B, Orend G*. 2011. Advances in Tenascin-C biology. Invited review in a special issue on "Emerging Functions of Matricellular Proteins" in Cellular and Molecular Life Sciences (CMLS), David Roberts editor, 68:3175-99.* co-corresponding authors

Spenlé C, Hussenet T, Lacroute J, Lefebvre O, Kedinger M, Orend G, & Simon-Assmann P. 2011. Dysregulation of laminins in intestinal inflammation. Special issue, Pathologie Biologie, 60:41-47.

2010

Gasser I*, Bouakaze C*, Eschbach J*, Fouquerel E*, Kieffer E*, Krieger S.*, Milosevic S*, Saandi T*, Florentz C, Maréchal-Drouard L, & Labouesse M. 2010. “OpenLAB”: A 2-hour PCR-based practical for high school students. Biochemistry and Molecular Biology Education 38:296-302 (* equal contribution, listed in alphabetical order)

Wang Z, Collighan RJ, Gross SR, Danen EH, Orend G, Telci D, & Griffin M. 2010. RGD-independent cell adhesion via a tissue transglutaminase-fibronectin matrix promotes fibronectin fibril deposition and requires syndecan-4/2 and α5β1 integrin co-signalling. J Biol Chem 285:40212-40229.

Richard D, Nguyen I, Affolter C, Meyer F, Schaaf P, Voegel JC, Bagnard D, & Ogier J. 2010. Polyelectrolyte multilayer-mediated gene delivery for semaphorin signaling pathway control. Small 6:2405-2411.

Nasarre C, Roth M, Jacob L, Roth L, Koncina E, Thien A, Labourdette G, Poulet P, Hubert P, Cremel G, Roussel G, Aunis D, & Bagnard D. 2010. Peptide-based interference of the transmembrane domain of neuropilin-1 inhibits glioma growth in vivo. Oncogene 29:2381-2392.

Hubert P, Sawma P, Duneau JP, Khao J, Henin J, Bagnard D, & Sturgis J. 2010. Single-spanning transmembrane domains in cell growth and cell-cell interactions: More than meets the eye? Cell Adh Migr 4:313-324.

Edwards MM, Mammadova-Bach E, Alpy F, Klein A, Hicks WL, Roux M, Simon- Assmann P, Smith RS, Orend G, Wu J, Peachey NS, Naggert JK, Lefebvre O*, & Nishina PM*. 2010. Mutations in Lama1 disrupt retinal vascular development and inner limiting membrane formation. J Biol Chem 285:7697-7711. * co-corresponding authors

Zboralski D, Warscheid B, Klein-Scory S, Malas MB, Becker H, Böckmann M, Meyer HE, Schmiegel W, Simon-Assmann P, & Schwarte-Waldhoff I. 2010. Uncoupled responses of Smad4-deficient cancer cells to TNFalpha result in secretion of monomeric laminin-gamma2. Mol Cancer 9:65-77.

Hussenet T*, Dembélé D, Martinet N, Vignaud JM, du Manoir S*. 2010. An adult tissue-specific stem cell molecular phenotype is activated in epithelial cancer stem cells and correlated to patient outcome. Cell Cycle 9:321-327. *co-corresponding authors

Hussenet T*, du Manoir S. 2010. SOX2 in squamous cell carcinoma: amplifying a pleiotropic oncogene along carcinogenesis. Cell Cycle 9:1480-1486. *corresponding author

Vlastos F, Zinszner J, Hussenet T, du Manoir S, Vordonis L, Nikolakopoulou S, Hardavella G, Lacomme S, Vignaud JM, Martinet N. 2010. Mapping EGFR1 mutations in patients with lung adenocarcinoma. Diagn Mol Pathol 19:209-217.

Langlois B, Perrot G, Schneider C, Henriet P, Emonard H, Martiny L, Dedieu S.  2010. LRP1 promotes cancer cell invasion by supporting ERK and inhibiting JNK signaling. PLoS One 7, e11584.